There are 4 major mfg of hydroxychloroquine in the world. China, Germany, India and Israel. Germany and India are hoarding production and blocked exports to the United States. China not shipping any , don't know their policy.

[BLA + 1,666]

Bayer sent 3 million pills before export ban.  Teva sending 6 million units now. India's Sun Pharma sent 2.5 million units before the government banned it's export.  Don't expect help from China. They control some basic ingredience needed to mfg HCQ.  U.S. in tough position. 

These manufacturers can ramp production but U.S. access to the supply may be limited. Per the French trial protocol each patient was given 3 200mg pills a day for 10 days = 30 pills

Edited March 29, 2020 by BLA

[Yoshiro Kamamura + 274]

The drug is not proven to be effective for COVID-19, and lupus patients need it to treat their condition.

[Yoshiro Kamamura + 274]

 

Vital drug for people with lupus running out after unproven Covid-19 link

https://www.theguardian.com/world/2020/mar/27/vital-drug-people-lupus-coronavirus-covid-19-link-hydroxychloroquine

Italy and France now prescribing hydroxychloroquine for coronavirus despite fact its effectiveness is unknown

 

A stampede for an unproven “cure” for Covid-19 is clearing the pharmacy shelves of a medicine that is vital for up to 5 million people around the world suffering from lupus, as countries bow to populist pressure and abandon the trials that would show whether hydroxychloroquine works against coronavirus infection.

Both Italy and France have said doctors can now prescribe hydroxychloroquine – a less toxic version of the malaria drug chloroquine – even though there is no robust evidence to prove that it is effective against Covid-19.

Popular pressure for access to the drug has been ramped up by pronouncements from presidents Donald Trump in the US and Jair Bolsonaro in Brazil, both of whom have claimed it is a cure. An Australian businessman, the former politician Clive Palmer, has pledged to fund 1m doses “to ensure all Australians would have access to the drug as soon as possible”.

But the drug is already running out for people with lupus, a disorder of the immune system, who rely on it to stay well. Shortages are being reported from the UK to Thailand to France. India, which manufactures the raw ingredient, has banned all exports of the chemical to safeguard its own supplies and recommended all health workers to take the drug to protect themselves from the virus.

“We are incredibly concerned at the moment,” said Paul Howard of Lupus UK. “We started receiving inquiries from patients across the UK about a week ago. That’s been rapidly increasing – more and more people each day.”

For 90% of the more than 60,000 people in the UK with lupus, hydroxychloroquine is the mainstay of their treatment, preventing their immune system making too many antibodies, which can otherwise attack the body’s organs – mainly the kidneys and the skin, but also the heart, lungs and brain.

“Their local pharmacies don’t have any stocks available on the shelves,” said Howard. “They have no date for when they can expect stocks to arrive.”

There is no good alternative, he said. Other immunosuppressants have toxic side-effects and may put people at greater risk of Covid-19.

A nationalistic scramble is now on around the world to secure supplies of hydroxychloroquine in spite of the absence of rigorous evidence in the treatment of the coronavirus. One small trial in China produced good results, but was far from sufficient to show that it works.

In France, the government caved to pressure from a doctor who ran his own very small and rapid trial of the drug combined with an antibiotic in 26 people, using methodology that has been seriously criticised. Dr Didier Raoult, a professor of infectious diseases who works at La Timone hospital in Marseille, then declared in a video on YouTube that chloroquine was a cure for Covid-19 and should be used immediately.

Raoult walked out of the scientific advisory committee advising the government. A social media frenzy began, with allegations that the government was being influenced by the big pharmaceutical companies which wanted to block hydroxychloroquine because it was cheap, being out of patent. People queued outside Raoult’s hospital to be tested and get the drug, defying the lockdown. Finally, the French government gave way and decreed that hospitals could prescribe it for any Covid-19 patient. They can also give the anti-HIV medicine which is supposed to be in global trials for Covid-19, Kaletra, which is a combination of lopinavir and ritonavir.

Italy has followed suit. The government announced on Friday that chloroquine and hydroxychloroquine could be used to treat all Covid-19 patients and paid for entirely by the Italian national healthcare system. It would also pay for Kaletra.

The impact on the global trials to find out what really works is serious. Nick White, a professor of tropical medicine at Mahidol University in Thailand and at the University of Oxford, says the problem is enormous – not so much for malaria, where the drug is now less used, but for lupus patients and for hopes of finding out what works and sharing it globally.

“From Fauci [US government infectious diseases adviser, Dr Anthony Fauci] to the head of the World Health Organization, everyone says trials. It may be worse than nothing. We don’t know,” he said.

“The nationalistic shuttering down of export and import of drugs is serious. Drugs are manufactured in relatively small numbers of places and have to be moved to other places.

“The indirect harm could be worse than the impact of Covid-19,” he said. “it is not just the drugs that might work. It is all drugs. Italy, for instance, is a major source of drugs for the NHS. This is a very big area. It is getting bigger by the minute. And the opportunity to answer the sensible question – do these things work, yes or no? – is narrowing as countries become more nationalistic in terms of hoarding drugs.”

[0R0 + 6,251]

19 hours ago, Yoshiro Kamamura said:

A stampede for an unproven “cure” for Covid-19 is clearing the pharmacy shelves of a medicine that is vital for up to 5 million people around the world suffering from lupus, as countries bow to populist pressure and abandon the trials that would show whether hydroxychloroquine works against coronavirus infection.

 

So far, stats from his broader test are in and look as good even on more advanced cases.

Thousands of successful treatments are reported and being documented. Stats will be out soon enough. 

The trials will happen anyway and will stop when the stats on efficacy are clear. 

Teva can ramp up production in Israel and other plants. In the US Mylan has taken its old plant out of mothballs. No time table yet as to how long till it starts output. Similarly, we need to look at making large amounts of zithromax. It is not hard to make the HCQ as I am told. 

You are being counterproductive. 

[Enthalpic + 1,496]

A small molecule, any decent universities chemistry / pharmacology department could produce some.

Revamp of a pharmaceuticals companies' production would probably be fairly easy - but we need more profitable Viagra in these social distancing times. joke.

Local distilleries have switched to making hand sanitizer....

Edited March 28, 2020 by Enthalpic

[BLA + 1,666]

18 hours ago, 0R0 said:

So far, stats from his broader test are in and look as good even on more advanced cases.

Thousands of successful treatments are reported and being documented. Stats will be out soon enough. 

The trials will happen anyway and will stop when the stats on efficacy are clear. 

Teva can ramp up production in Israel and other plants. In the US Mylan has taken its old plant out of mothballs. No time table yet as to how long till it starts output. Similarly, we need to look at making large amounts of zithromax. It is not hard to make the HCQ as I am told. 

You are being counterproductive. 

A basic material required to mfg HCQ is controlled by the Chinese.

So far they are stiffing U.S.

Trump sucking up to Xi.  Hopefully it works.

Also, Two major manufacturers Germany and India has banned export of HCQ.  Not Good. 

Take care of the virus now.

There will be plenty of time to address China's behavior later. 

Key to U.S. control are (1) the new ABBOTT LABS test kits (under 15 minutes test to results) and the (2) distribution of HCQ/ZPAK. 

 

Edited March 29, 2020 by BLA

[Gerry Maddoux + 3,627]

18 hours ago, 0R0 said:

Teva can ramp up production in Israel and other plants. In the US Mylan has taken its old plant out of mothballs. No time table yet as to how long till it starts output. Similarly, we need to look at making large amounts of zithromax. It is not hard to make the HCQ as I am told. 

Both HCQ and Z are relatively easy to manufacture . . . and I'm pretty sure those recipes are being shared by the pharmaceutical community. If nothing else, it sure appears that the combo reduces infectivity in those with early Covid-19. 

There's obviously a problem with testing for the "19" specifically . . . as coronaviruses are everywhere at this point. Each virus that infects us leaves behind a little dab of DNA--in your (host) DNA. These usually become part of the "nonsensical" codons within every person's DNA. 

With the testing kits, I'm told that anyone who has a snippet of coronavirus (we've mostly all been infected by at least one) within his or her DNA will test positive for the 19. I am not sure this is true, just what I've learned from people who are usually right. 

Anyway, it would appear that HCQ is pretty alkaline (I seem to remember this, once prodded). The virus needs an acidic environment in order to replicate. HCQ may prevent replication and shedding. 

Probably the reason the FDA is moving so slowly on this is because both Zithromax and HCQ have the ability to pervert the ECG: by QT prolongation (which can lead to death in certain patients). Additionally, either drug can suppress myocardial contractility. These are dangerous actions in the most vulnerable patient subset. 

And a few people have died from self-medication--always a dangerous thing to do. Some idiot in my area dosed himself with chloroquine phosphate used to clean aquariums. He died. His wife went along too but survived.  

All in all, it would appear that the best way to corral this thing is by giving HCQ/Z to relatively healthy people with an extensive exposure to other people: hospital workers, supermarket and pharmacy workers, fast-food and food delivery workers, and the like. It is really a matter of thinning out the crowd of "spreaders" until the Marshall Plan (Barron's description) of multi-drug discipline gets going. 

Edited March 29, 2020 by Gerry Maddoux

[BLA + 1,666]

3 hours ago, Gerry Maddoux said:

Both HCQ and Z are relatively easy to manufacture . . . and I'm pretty sure those recipes are being shared by the pharmaceutical community. If nothing else, it sure appears that the combo reduces infectivity in those with early Covid-19. 

There's obviously a problem with testing for the "19" specifically . . . as coronaviruses are everywhere at this point. Each virus that infects us leaves behind a little dab of DNA--in your (host) DNA. These usually become part of the "nonsensical" codons within every person's DNA. 

With the testing kits, I'm told that anyone who has a snippet of coronavirus (we've mostly all been infected by at least one) within his or her DNA will test positive for the 19. I am not sure this is true, just what I've learned from people who are usually right. 

Anyway, it would appear that HCQ is pretty alkaline (I seem to remember this, once prodded). The virus needs an acidic environment in order to replicate. HCQ may prevent replication and shedding. 

Probably the reason the FDA is moving so slowly on this is because both Zithromax and HCQ have the ability to pervert the ECG: by QT prolongation (which can lead to death in certain patients). Additionally, either drug can suppress myocardial contractility. These are dangerous actions in the most vulnerable patient subset. 

And a few people have died from self-medication--always a dangerous thing to do. Some idiot in my area dosed himself with chloroquine phosphate used to clean aquariums. He died. His wife went along too but survived.  

All in all, it would appear that the best way to corral this thing is by giving HCQ/Z to relatively healthy people with an extensive exposure to other people: hospital workers, supermarket and pharmacy workers, fast-food and food delivery workers, and the like. It is really a matter of thinning out the crowd of "spreaders" until the Marshall Plan (Barron's description) of multi-drug discipline gets going. 

Pray CV19 doesn't mutate into a far more deadlier version like the 1918 Spanish Flu did.  U.S. will be the most vulnerable country without sufficient supply of HCQ/Z

Agreed, we need multiple solutions , however HCQ is the only one available now and expected for the immediate future.

The just released second French test was run using 80 Hospitalized Patients.  The only population that showed no success were those very far along with the disease ,  on ventilators. 

CV19 is an RNA virus vs a DNA virus.  They tend to mutate much easier.  

Edited March 29, 2020 by BLA

[BLA + 1,666]

29 minutes ago, Gerry Maddoux said:

Both HCQ and Z are relatively easy to manufacture . . . and I'm pretty sure those recipes are being shared by the pharmaceutical community. If nothing else, it sure appears that the combo reduces infectivity in those with early stage

They are relatively easy to mfg . .  .  .  .  If you have the basic ingredience .  .  .  

CHINA DOES 

U.S. DOES NOT

That's why China has asked the U.S. to lift the remaining  tariffs on the $250 Billion product. .  .  .  

.  .  .  and the U.S. is considering their request

Edited March 29, 2020 by BLA

[Enthalpic + 1,496]

28 minutes ago, BLA said:

They are relatively easy to mfg . .  .  .  .  If you have the basic ingredience .  .  .  

CHINA DOES 

U.S. DOES NOT

That's why China has asked the U.S. to lift the remaining  tariffs on the $250 Billion product. .  .  .  

.  .  .  and the U.S. is considering their request

Bull shit

I can make this shit with in stock stuff from Fisher Sci

Catalysts can be regenerated

The rest is organic chemicals - petrochemical feedstocks

 

Edited March 29, 2020 by Enthalpic

[BLA + 1,666]

1 hour ago, Enthalpic said:

Bull shit

I can make this shit with in stock stuff from Fisher Sci

Catalysts can be regenerated

The rest is organic chemicals - petrochemical feedstocks

 

You should start.  The pharmacies are running out of stock.  

Make millions !

You have a list of ingredience ?

Edited March 29, 2020 by BLA

[0R0 + 6,251]

1 hour ago, BLA said:

They are relatively easy to mfg . .  .  .  .  If you have the basic ingredience .  .  .  

CHINA DOES 

U.S. DOES NOT

That's why China has asked the U.S. to lift the remaining  tariffs on the $250 Billion product. .  .  .  

.  .  .  and the U.S. is considering their request

I would say China can put a $4 Trillion dollar reparation, give the pharma ingredients gratis, and then we lift the tariffs. Threaten China with a class action law suit for the entirety of economic losses in the US for both individuals businesses and financial institutions and the likelihood that they will lose all of the Chinese owned property around the globe. That during the trial, thousands of hours of video showing the expanding death toll and bodies taken off the street in Wuhan while in the foreground would be quotes of Chinese officials lying about the virus and the disease it causes. Particularly playing down its contagion. China and its individual leaders can find their property on the line. 

Immediately after the CV19 is taken down, there is a falling quota on importing any pharmaceutical ingredient or medical equipment from china till there is nothing at all coming from China by 2025. 

I would check to see if the supply chain from basic ingredients is possible in the US and how rapidly it can be built up. I am certain there is a pharma advisory group telling the president what they can do, and what regulatory relief they need in order to do it. These are chemical plants and have EPA, FDA and state and local regulators acting as if they are enemies of humanity and a source of generating fines for government income. The regulatory system is 60% of the cost of a chemical plant, 80% of a pharmaceutical plant. Trump has to figure out how to lift the restrictions and compliance demands so that they can build first and prove compliance later. The war powers should help there. 

If it proves possible, then the plant construction should go ahead and the tariffs RAISED and quotas imposed.

There should be no advantage provided to China through this extortion. 

[0R0 + 6,251]

1 hour ago, Enthalpic said:

Bull shit

I can make this shit with in stock stuff from Fisher Sci

Catalysts can be regenerated

The rest is organic chemicals - petrochemical feedstocks

 

OK

Lets' look it up and go do it, if there isn't already a $1 Billion plant being built on a cost plus contract as we speak. 

[0R0 + 6,251]

https://www.pharmtech.com/suppliers-plan-chloroquine-capacity

I don't know where the precursor's to Mylan's plant will be coming from.

 

[0R0 + 6,251]

https://www.sciencedirect.com/topics/chemistry/chloroquine

synthesis

 

[Gerry Maddoux + 3,627]

2 hours ago, BLA said:

CV19 is an RNA virus vs a DNA virus.  They tend to mutate much easier.  

Correct. There is a young guy named Bedford, who has tracked this virus's genome from Wuhan to Seattle, throughout the world. He records an up-to-date phylogenetic tree on NextStrain. This one is mutating at a rate of 24/year, which is pretty slow for an RNA virus. 

Vis a vis the manufacture of HCQ and Zithromax, both are fairly easy to build. HCQ is just Chloroquine--the ancient malarial drug, with an hydroxyl group added because so many strains of the Falciparum malaria were getting resistant. President Xi has to know that China's standing in the world community has sunk to a very deep low--just today a representative from the UK said their thinking was that t he Wuhan virus hit 15 to 40 times more people than was reported, with a correspondingly awful mortality (which would correlate with the mercury from amalgams and the sulfur readings from a sampling of the air above Wuhan). He might just open up and send some HCQ our way, but we can't count on that. 

Remviradir is likely working on advanced cases, as they are talking it up more. 

[BLA + 1,666]

17 minutes ago, Gerry Maddoux said:

Correct. There is a young guy named Bedford, who has tracked this virus's genome from Wuhan to Seattle, throughout the world. He records an up-to-date phylogenetic tree on NextStrain. This one is mutating at a rate of 24/year, which is pretty slow for an RNA virus. 

Vis a vis the manufacture of HCQ and Zithromax, both are fairly easy to build. HCQ is just Chloroquine--the ancient malarial drug, with an hydroxyl group added because so many strains of the Falciparum malaria were getting resistant. President Xi has to know that China's standing in the world community has sunk to a very deep low--just today a representative from the UK said their thinking was that t he Wuhan virus hit 15 to 40 times more people than was reported, with a correspondingly awful mortality (which would correlate with the mercury from amalgams and the sulfur readings from a sampling of the air above Wuhan). He might just open up and send some HCQ our way, but we can't count on that. 

Remviradir is likely working on advanced cases, as they are talking it up more. 

What is best case for Remiradir approval. 

Fauci has started to stockpile

Edited March 29, 2020 by BLA

[BLA + 1,666]

43 minutes ago, 0R0 said:

I would say China can put a $4 Trillion dollar reparation, give the pharma ingredients gratis, and then we lift the tariffs. Threaten China with a class action law suit for the entirety of economic losses in the US for both individuals businesses and financial institutions and the likelihood that they will lose all of the Chinese owned property around the globe. That during the trial, thousands of hours of video showing the expanding death toll and bodies taken off the street in Wuhan while in the foreground would be quotes of Chinese officials lying about the virus and the disease it causes. Particularly playing down its contagion. China and its individual leaders can find their property on the line. 

Immediately after the CV19 is taken down, there is a falling quota on importing any pharmaceutical ingredient or medical equipment from china till there is nothing at all coming from China by 2025. 

I would check to see if the supply chain from basic ingredients is possible in the US and how rapidly it can be built up. I am certain there is a pharma advisory group telling the president what they can do, and what regulatory relief they need in order to do it. These are chemical plants and have EPA, FDA and state and local regulators acting as if they are enemies of humanity and a source of generating fines for government income. The regulatory system is 60% of the cost of a chemical plant, 80% of a pharmaceutical plant. Trump has to figure out how to lift the restrictions and compliance demands so that they can build first and prove compliance later. The war powers should help there. 

If it proves possible, then the plant construction should go ahead and the tariffs RAISED and quotas imposed.

There should be no advantage provided to China through this extortion. 

Can't imagine that scenario, but would be something to watch.

Sure, go for it 

[BLA + 1,666]

Just now, BLA said:

to

 

42 minutes ago, 0R0 said:

https://www.pharmtech.com/suppliers-plan-chloroquine-capacity

I don't know where the precursor's to Mylan's plant will be coming from.

 

I read an article about the French trial.

They said pre crisis one could buy ten pills for 1 Euro

[Enthalpic + 1,496]

34 minutes ago, 0R0 said:

https://www.sciencedirect.com/topics/chemistry/chloroquine

synthesis

 

Easy

 

[0R0 + 6,251]

2 minutes ago, BLA said:

Can't imagine that scenario, but would be something to watch.

Sure, go for it 

China is already being sued as a case is waiting certification as a class action. Many others are coming.

The Chinese are thinking upside down, as usual. They breached the rules of behavior of civilized people by deliberately putting the world in danger. There is every chance that Chinese property associated with the state and the CCP leadership - meaning nearly all of it (but for real estate), will be confiscated as reparations. 

Their thinking that their strategic capture of pharmaceutical supply chains gives them leverage is only true against small countries in dire straits. Against the entire world it means that they are going to be threatened with a blockade and eventual total isolation if the ingredients don't come out gratis. 

[0R0 + 6,251]

2 minutes ago, BLA said:

 

I read an article about the French trial.

They said pre crisis one could buy ten pills for 1 Euro

The combo HCQ/Z was priced at under $50 for a 10 day course a la Dr Raoult's prescription

[Enthalpic + 1,496]

55 minutes ago, 0R0 said:

OK

Lets' look it up and go do it, if there isn't already a $1 Billion plant being built on a cost plus contract as we speak. 

https://www.ebay.ca/i/362523861586?chn=ps&norover=1&mkevt=1&mkrid=706-89093-2056-0&mkcid=2&itemid=362523861586&targetid=889389703132&device=c&mktype=pla&googleloc=9061281&poi=&campaignid=9561945102&mkgroupid=98506997979&rlsatarget=pla-889389703132&abcId=1063836&merchantid=10252592&gclid=EAIaIQobChMIlZreo8fA6AIVJBh9Ch2cNAXUEAYYAyABEgLXYfD_BwE

https://www.usalab.com/10l-round-bottom-boiling-flask-3-neck-1-24-40-and-2-34-45/

 

[Enthalpic + 1,496]

Would need many of each with heating mantles and reflux condensors

Edited March 29, 2020 by Enthalpic

[Enthalpic + 1,496]

Addition funnels

https://www.fishersci.com/shop/products/kontes-ptfe-plug-stopcocks-graduations-pressure-equalizing-lines-ground-joint-funnels-6/p-129045